American Airlines flight AA 4541: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Mon-Sat 06:10 Ronald Reagan Washington (DCA) 2 07:20 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:10 Effective 2025-06-05 through 2025-07-04
Mon-Sat 06:10 Ronald Reagan Washington (DCA) 2 07:21 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:11 Effective 2025-07-05 through 2025-08-05
Daily 06:28 Ronald Reagan Washington (DCA) 2 07:27 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 0:59 Effective 2025-08-06 through 2025-09-02
Daily 06:30 Ronald Reagan Washington (DCA) 2 07:30 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:00 Effective 2025-09-03 through 2025-10-05
Daily 06:30 Ronald Reagan Washington (DCA) 2 07:33 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:03 Effective 2025-10-06 through 2025-11-01
Daily 08:13 New York LaGuardia (LGA) B 10:34 Knoxville (TYS)
AA 4541 Non-stop Embraer EMB 175 (E75) 2:21 Effective 2025-11-02 through 2025-12-02
Daily 08:23 New York LaGuardia (LGA) B 10:39 Knoxville (TYS)
AA 4541 Non-stop Embraer EMB 175 (E75) 2:16 Effective 2025-12-03 through 2025-12-17
Daily 08:27 New York LaGuardia (LGA) B 10:51 Knoxville (TYS)
AA 4541 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-01-06 through 2026-02-11
Daily 08:45 New York LaGuardia (LGA) B 11:01 Knoxville (TYS)
AA 4541 Non-stop Embraer EMB 175 (E75) 2:16 Effective 2025-12-18 through 2026-01-05
Daily 08:45 New York LaGuardia (LGA) B 11:13 Knoxville (TYS)
AA 4541 Non-stop Embraer EMB 175 (E75) 2:28 Effective from 2026-02-12
Mon,Thu,Fri,Sun 10:40 Philadelphia (PHL) 12:39 Cincinnati (CVG)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:59 Effective 2025-05-08 through 2025-05-23
Mon,Thu-Sun 10:40 Philadelphia (PHL) 12:39 Cincinnati (CVG)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:59 Effective 2025-05-24 through 2025-06-02
Daily 11:04 Knoxville (TYS) 12:59 New York LaGuardia (LGA) B
AA 4541 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2025-11-02 through 2025-12-02
Daily 11:09 Knoxville (TYS) 13:07 New York LaGuardia (LGA) B
AA 4541 Non-stop Embraer EMB 175 (E75) 1:58 Effective 2025-12-03 through 2025-12-17
Daily 11:21 Knoxville (TYS) 13:19 New York LaGuardia (LGA) B
AA 4541 Non-stop Embraer EMB 175 (E75) 1:58 Effective 2026-01-06 through 2026-02-11
Daily 11:38 Knoxville (TYS) 13:33 New York LaGuardia (LGA) B
AA 4541 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2025-12-18 through 2026-01-05
Daily 12:03 Knoxville (TYS) 14:00 New York LaGuardia (LGA) B
AA 4541 Non-stop Embraer EMB 175 (E75) 1:57 Effective from 2026-02-12
Mon,Thu,Fri,Sun 13:09 Cincinnati (CVG) 14:51 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2025-05-08 through 2025-05-23
Mon,Thu-Sun 13:09 Cincinnati (CVG) 14:51 Philadelphia (PHL)
AA 4541 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2025-05-24 through 2025-06-02
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4541: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4541
06:10
Ronald Reagan Washington (DCA) 2

07:20
Philadelphia (PHL)
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
-
Duration: 1:10, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
06:10
Ronald Reagan Washington (DCA) 2

07:21
Philadelphia (PHL)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
-
Duration: 1:11, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
06:28
Ronald Reagan Washington (DCA) 2

07:27
Philadelphia (PHL)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 0:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
06:30
Ronald Reagan Washington (DCA) 2

07:30
Philadelphia (PHL)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:00, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
06:30
Ronald Reagan Washington (DCA) 2

07:33
Philadelphia (PHL)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:03, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
08:13
New York LaGuardia (LGA) B

10:34
Knoxville (TYS)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:21, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
08:23
New York LaGuardia (LGA) B

10:39
Knoxville (TYS)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:16, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
08:27
New York LaGuardia (LGA) B

10:51
Knoxville (TYS)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
08:45
New York LaGuardia (LGA) B

11:01
Knoxville (TYS)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:16, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
08:45
New York LaGuardia (LGA) B

11:13
Knoxville (TYS)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
10:40
Philadelphia (PHL)

12:39
Cincinnati (CVG)
Effective 2025-05-08 through 2025-05-23
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
10:40
Philadelphia (PHL)

12:39
Cincinnati (CVG)
Effective 2025-05-24 through 2025-06-02
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
11:04
Knoxville (TYS)

12:59
New York LaGuardia (LGA) B
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
11:09
Knoxville (TYS)

13:07
New York LaGuardia (LGA) B
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:58, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
11:21
Knoxville (TYS)

13:19
New York LaGuardia (LGA) B
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:58, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
11:38
Knoxville (TYS)

13:33
New York LaGuardia (LGA) B
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
12:03
Knoxville (TYS)

14:00
New York LaGuardia (LGA) B
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:57, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
13:09
Cincinnati (CVG)

14:51
Philadelphia (PHL)
Effective 2025-05-08 through 2025-05-23
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
American Airlines AA4541
13:09
Cincinnati (CVG)

14:51
Philadelphia (PHL)
Effective 2025-05-24 through 2025-06-02
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Knoxville (TYS) - New York LaGuardia (LGA)
  • Philadelphia (PHL) - Cincinnati (CVG)
  • Ronald Reagan Washington (DCA) - Philadelphia (PHL)
All American Airlines flights
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