American Airlines flight AA 2281: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 05:18 Lexington (LEX) 06:40 Charlotte (CLT)
AA 2281 Non-stop Airbus A319 (319) 1:22 Effective 2025-10-06 through 2025-10-25
Daily 05:38 Memphis (MEM) 08:25 Charlotte (CLT)
AA 2281 Non-stop Airbus A321 (321) 1:47 Effective 2025-12-03 through 2025-12-17
Daily 20:35 Chicago O'Hare (ORD) 3 23:26 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:51 Valid until 2025-05-04
Daily 20:35 Chicago O'Hare (ORD) 3 23:23 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:48 Effective 2025-05-05 through 2025-06-03
Wed 20:35 Chicago O'Hare (ORD) 3 23:23 Dallas Fort Worth (DFW)
AA 2281 Non-stop Boeing 737-800 (738) 2:48 Operates only on 2025-06-04
Daily 20:36 Chicago O'Hare (ORD) 3 23:30 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:54 Effective 2025-07-05 through 2025-08-05
Daily 20:36 Chicago O'Hare (ORD) 3 23:30 Dallas Fort Worth (DFW)
AA 2281 Non-stop Boeing 737-800 (738) 2:54 Effective 2025-08-06 through 2025-09-02
Daily 20:36 Chicago O'Hare (ORD) 3 23:30 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:54 Effective 2025-09-03 through 2025-10-05
Daily 20:40 Chicago O'Hare (ORD) 3 23:30 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:50 Effective 2025-06-05 through 2025-06-30
Wed,Thu 20:40 Chicago O'Hare (ORD) 3 23:30 Dallas Fort Worth (DFW)
AA 2281 Non-stop Airbus A321 (321) 2:50 Effective 2025-07-02 through 2025-07-03
Daily 22:30 Dallas Fort Worth (DFW) 23:42 San Antonio (SAT)
AA 2281 Non-stop Airbus A321 (321) 1:12 Effective 2025-10-26 through 2025-11-01
Daily 22:30 Dallas Fort Worth (DFW) 23:45 San Antonio (SAT)
AA 2281 Non-stop Boeing 737-800 (738) 1:15 Effective 2025-11-02 through 2025-12-02
Daily 22:30 Dallas Fort Worth (DFW) 23:46 San Antonio (SAT)
AA 2281 Non-stop Boeing 737-800 (738) 1:16 Effective 2025-12-18 through 2026-01-05
Daily 22:30 Dallas Fort Worth (DFW) 23:48 San Antonio (SAT)
AA 2281 Non-stop Airbus A321 (321) 1:18 Effective 2026-01-06 through 2026-02-11
Daily 22:55 Dallas Fort Worth (DFW) 00:08 San Antonio (SAT)
AA 2281 Non-stop Boeing 737-800 (738) 1:13 Effective from 2026-02-12
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:


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American Airlines flight AA 2281: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA2281
05:18
Lexington (LEX)

06:40
Charlotte (CLT)
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:22, non-stop
Airbus A319 (319)
American Airlines AA2281
05:38
Memphis (MEM)

08:25
Charlotte (CLT)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:47, non-stop
Airbus A321 (321)
American Airlines AA2281
20:35
Chicago O'Hare (ORD) 3

23:26
Dallas Fort Worth (DFW)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:51, non-stop
Airbus A321 (321)
American Airlines AA2281
20:35
Chicago O'Hare (ORD) 3

23:23
Dallas Fort Worth (DFW)
Effective 2025-05-05 through 2025-06-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:48, non-stop
Airbus A321 (321)
American Airlines AA2281
20:35
Chicago O'Hare (ORD) 3

23:23
Dallas Fort Worth (DFW)
Operates only on 2025-06-04
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:48, non-stop
Boeing 737-800 (738)
American Airlines AA2281
20:36
Chicago O'Hare (ORD) 3

23:30
Dallas Fort Worth (DFW)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:54, non-stop
Airbus A321 (321)
American Airlines AA2281
20:36
Chicago O'Hare (ORD) 3

23:30
Dallas Fort Worth (DFW)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:54, non-stop
Boeing 737-800 (738)
American Airlines AA2281
20:36
Chicago O'Hare (ORD) 3

23:30
Dallas Fort Worth (DFW)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:54, non-stop
Airbus A321 (321)
American Airlines AA2281
20:40
Chicago O'Hare (ORD) 3

23:30
Dallas Fort Worth (DFW)
Effective 2025-06-05 through 2025-06-30
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:50, non-stop
Airbus A321 (321)
American Airlines AA2281
20:40
Chicago O'Hare (ORD) 3

23:30
Dallas Fort Worth (DFW)
Effective 2025-07-02 through 2025-07-03
Mon
-
Tue
-
Wed
Thu
Fri
-
Sat
-
Sun
-
Duration: 2:50, non-stop
Airbus A321 (321)
American Airlines AA2281
22:30
Dallas Fort Worth (DFW)

23:42
San Antonio (SAT)
Effective 2025-10-26 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:12, non-stop
Airbus A321 (321)
American Airlines AA2281
22:30
Dallas Fort Worth (DFW)

23:45
San Antonio (SAT)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:15, non-stop
Boeing 737-800 (738)
American Airlines AA2281
22:30
Dallas Fort Worth (DFW)

23:46
San Antonio (SAT)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:16, non-stop
Boeing 737-800 (738)
American Airlines AA2281
22:30
Dallas Fort Worth (DFW)

23:48
San Antonio (SAT)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:18, non-stop
Airbus A321 (321)
American Airlines AA2281
22:55
Dallas Fort Worth (DFW)

00:08(+1)
San Antonio (SAT)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:13, non-stop
Boeing 737-800 (738)
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - Dallas Fort Worth (DFW)
  • Dallas Fort Worth (DFW) - San Antonio (SAT)
  • Lexington (LEX) - Charlotte (CLT)
  • Memphis (MEM) - Charlotte (CLT)
All American Airlines flights
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